Aberrant repair and fibrosis development in skeletal muscle
نویسندگان
چکیده
منابع مشابه
Macrophage Plasticity in Skeletal Muscle Repair
Macrophages are one of the first barriers of host defence against pathogens. Beyond their role in innate immunity, macrophages play increasingly defined roles in orchestrating the healing of various injured tissues. Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases. Heterogenei...
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Muscle fibrosis is a common Orthopaedic problem that results from tissue trauma, degeneration, neurotoxin injection and disuse. However, the interaction between skeletal muscle cells and the components of the extracellular matrix (ECM) that results in development of fibrotic tissue is not well understood. In this study, we have exploited the fact that the skeletal muscle intermediate filament p...
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In the late stages of muscle development, a unique cell population emerges that is a key player in postnatal muscle growth and muscle regeneration. The location of these cells next to the muscle fibers triggers their designation as satellite cells. During the healing of injured muscle tissue, satellite cells are capable of forming completely new muscle fibers or restoring damaged muscle fibers....
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Skeletal muscle is a highly specialized tissue composed of non-dividing, multi-nucleated muscle fibres that contract to generate force in a controlled and directed manner. Skeletal muscle is formed during embryogenesis from a subset of muscle precursor cells, which generate both differentiated muscle fibres and specialized muscle-forming stem cells known as satellite cells. Satellite cells rema...
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ژورنال
عنوان ژورنال: Skeletal Muscle
سال: 2011
ISSN: 2044-5040
DOI: 10.1186/2044-5040-1-21